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defeatHIV

We are scientists, clinicians and community working together
to find a cure for HIV.

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Home: Who We Are

defeatHIV is
Cell and Gene Therapy for HIV Cure

defeatHIV is a Collaboratory of leading scientists and clinicians in the fields of HIV, cell and gene therapies, pre-clinical models, and clinical research, partnered with a strong team of community advocates, united by a shared vision: finding a cure for HIV. Founded in 2011 and led by Drs. Keith Jerome and Hans-Peter Kiem at Fred Hutchinson Cancer Research Center in Seattle, WA, defeatHIV continues pushing HIV cure research and advocacy forward.


Fred Hutch is the birthplace of bone marrow transplantation and a pioneering hub of immunotherapy development.The late Dr. E. Donnall “Don” Thomas, a founding faculty member of Fred Hutch, received the 1990 Nobel Prize in physiology or medicine for establishing bone marrow and blood stem cell transplantation as a lifesaving treatment for leukemia and other blood diseases.


defeatHIV investigators are extending this legacy to HIV, trying to understand how bone marrow transplantation cured the HIV infection in Timothy Ray Brown. We are leveraging these insights to develop potent cell and gene therapies that aim to eliminate HIV from where it lies dormant in the body, and revolutionize the way HIV is treated.

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COMMUNITY

Those who are affected by research have a right to be involved in the research-making process

defeatHIV is achieving more with our community engagement initiatives than ever before. We work on many exciting projects to help improve the understanding of difficult science, and are very proud of the progress we continue to make. Learn more about what we do, who we help, and how we work every day to promote positive change.

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One Step at a Time

Hugely popular last seven years, our educational events have drawn hundreds of people who want to interact more with the notable scientists and research participants dedicated to the same goal: curing HIV.

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Helping Researchers, Helping Community

defeatHIV CAB’s mission is to assure stakeholder perspectives, especially those of people living with HIV (PWH), are incorporated into defeatHIV’s decisions and activities.

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Reinforcing our Commitment

Using community-based participatory research (CBPR) methods, we seek to assess the acceptability of potential HIV cure research interventions, with a focus on cell and gene therapy.

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Upcoming Events

  • Pre CROI Community HIV Cure Research Workshop - Session 2
    Pre CROI Community HIV Cure Research Workshop - Session 2
    Fri, Mar 05
    https://bit.ly/3d1CgIX
    Mar 05, 2021, 9:00 AM – 11:00 AM PST
    https://bit.ly/3d1CgIX
    Mar 05, 2021, 9:00 AM – 11:00 AM PST
    https://bit.ly/3d1CgIX
    Our second session is dedicated to cell and gene therapy approaches to curing HIV. We'll give you an overview of the entire field, and then focus on some of the cutting edge work that has brought us closer to eradicating HIV from the body.
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  • Pre-CROI Community HIV Cure Research Workshop - Session1
    Pre-CROI Community HIV Cure Research Workshop - Session1
    Thu, Mar 04
    https://bit.ly/3p7Efh8
    Mar 04, 2021, 9:00 AM – 11:00 AM PST
    https://bit.ly/3p7Efh8
    Mar 04, 2021, 9:00 AM – 11:00 AM PST
    https://bit.ly/3p7Efh8
    An introduction to HIV cure-related research and discussions of community perspectives about a cure.
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  • MARCH CAB MEETING
    MARCH CAB MEETING
    Tue, Mar 02
    ZOOM
    Mar 02, 2021, 5:30 PM – 9:30 PM PST
    ZOOM
    Mar 02, 2021, 5:30 PM – 9:30 PM PST
    ZOOM
    Join us every first Tuesday of the month via Zoom. Send an email to mlouella@fredhutch.org for more details.
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NO CURE WITHOUT YOU #3
00:16
Can we cure HIV with an injection? | Dr. Hans-Peter Kiem | TEDxSeattle
15:57
TEDx Talks

Can we cure HIV with an injection? | Dr. Hans-Peter Kiem | TEDxSeattle

HIV was thought to be incurable, but after undergoing risky stem cell transplant surgeries, several patients no longer exhibit the deadly virus. Scientist Dr. Hans-Peter Kiem takes that idea a step further and shares his pioneering research using new gene-editing techniques. His bold vision may one day allow patients anywhere in the world to receive a single injection to stop HIV and other deadly diseases in their tracks. Special thanks to core the TEDxSeattle organizing team, 100+ volunteers, and our generous partners – without you, this experience would not be possible. Find out more about our talks, speakers, entertainers, activities, and year-round events at TEDxSeattle.com. In the spirit of ideas worth spreading, TEDx is a program of local, self-organized events that bring people together to share a TED-like experience. At a TEDx event, TED Talks video and live speakers combine to spark in-depth discussion and connection in a community setting. These events are branded TEDx, where x = independently organized TED event. The TED Conference provides general guidance for the TEDx program, but individual TEDx events are self-organized. Hans-Peter, the Director of the Stem Cell and Gene Therapy program at the Fred Hutchinson Cancer Research Center, is known as a pioneer in the development of new gene-editing technologies. Through his work as an oncologist providing bone marrow transplants to leukemia patients, Dr. Kiem learned it’s possible to modify genes in blood marrow stem cells and convey those genetic changes to a patient. Hans-Peter and his team hope to achieve cures for diseases like HIV, cancer, sickle cell anemia, and other blood disorders with this ability to repair or modify genes by editing stem cells to carry healthier or disease-resistant versions of genes before transplant. He is currently pioneering “in vivo” and “ex vivo” approaches to make gene therapy and gene editing more broadly available and accessible to those living with HIV, especially in resource-limited settings. He received his M.D. and Ph.D., at the University of Ulm in Germany. Hans-Peter came to the United States in 1988 and completed research at Stanford University. He received a degree in internal medicine at Vanderbilt University before an oncology fellowship at the University of Washington led to his work with the Fred Hutch. This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at https://www.ted.com/tedx Dr. Hans-Peter Kiem, the Director of the Stem Cell and Gene Therapy program at the Fred Hutchinson Cancer Research Center, is known as a pioneer in the development of new gene-editing technologies. Through his work as an oncologist providing bone marrow transplants to leukemia patients, Dr. Kiem learned it’s possible to modify genes in blood marrow stem cells and convey those genetic changes to a patient. Dr. Kiem and his team hope to achieve cures for diseases like HIV, cancer, sickle cell anemia and other blood disorders with this ability to repair or modify genes by editing stem cells to carry healthier or disease-resistant versions of genes prior to transplant. This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at https://www.ted.com/tedx
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1100 Fairview Ave N, E5-110, Seattle, WA 98109

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